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Pharmacodynamics Flutamide is a nonsteroidal antiandrogen In animal studies, flutamide demonstrates potent antiandrogenic effects It exerts its antiandrogenic action by inhibiting androgen uptake and or by inhibiting nuclear binding of androgen in target tissues or both Is flutamide a metabolite? What are the side effects of flutamide? Flutamide did not demonstrate DNA modifying activity in the Ames Salmonella microsome -- observed during a 6 week study of flutamide monotherapy in normal human volunteers Flutamide did not affect estrous cycles or interfere with the mating behavior of male and female rats when the drug was administered at 25 and 75 mg kg day prior to mating People also askFlutamide Dosage and Administration General In patients with stage B2 or C prostate cancer, initiate flutamide and LHRH analog 8 weeks prior to and continue during radiation therapy In patients with stage D2 metastatic prostate cancer, initiate flutamide and LHRH analog concomitantly and continue until disease progression Administration Flutamide has moderate interactions with at least 21 other drugs Flutamide has minor interactions with the following drugs : atazanavir; levoketoconazole; maitake; ribociclib; taurine; This information does not contain all possible interactions or adverse effects Visit the RxList Drug Interaction Checker for any drug interactions Flutamide belongs to a class of drugs known as anti-androgens (anti-testosterone) Testosterone, a natural hormone, helps prostate cancer to grow and spread Flutamide works by blocking the --- rxlist com flutamide generic-drug htmWhat are flutamide capsules used for? Flutamide did not affect estrous cycles or interfere with the mating behavior of male and female rats when the drug was administered at 25 and 75 mg kg day prior to mating Males treated with 150 mg kg day (30 times the minimum effective antiandrogenic dose) failed to mate; mating behavior returned to normal after dosing was stopped Flutamide belongs to a class of drugs known as anti-androgens (anti-testosterone) Testosterone, a natural hormone, helps prostate cancer to grow and spread Flutamide works by blocking the effects of testosterone, thereby slowing the growth and spread of prostate cancer --- medicine com drug flutamide hcpJun 14, 2024 · Flutamide side effects Get emergency medical help if you have signs of an allergic reaction to flutamide : hives; difficult breathing; swelling of your face, lips, tongue, or throat Flutamide can cause serious liver problems Call your doctor at once if you have: nausea, upper stomach pain, loss of appetite; itching, tiredness, flu-like symptoms; Flutamide has moderate interactions with at least 21 other drugs Flutamide has minor interactions with the following drugs: atazanavir; levoketoconazole; maitake; ribociclib; taurine; This information does not contain all possible interactions or adverse effects Visit the RxList Drug Interaction Checker for any drug interactions --- drugs com flutamide html--- drugs com monograph flutamide htmlSep 23, 2024 · Flutamide did not demonstrate DNA modifying activity in the Ames Salmonella microsome -- observed during a 6 week study of flutamide monotherapy in normal human volunteers Flutamide did not affect estrous cycles or interfere with the mating behavior of male and female rats when the drug was administered at 25 and 75 mg kg day prior to mating --- drugs com pro flutamide htmlFlutamide side effects Get emergency medical help if you have signs of an allergic reaction to flutamide: hives; difficult breathing; swelling of your face, lips, tongue, or throat Flutamide can cause serious liver problems Call your doctor at once if you have: nausea, upper stomach pain, loss of appetite; itching, tiredness, flu-like symptoms;Serious side effects of flutamide Along with its needed effects, flutamide may cause some unwanted effects Although not all of these side effects may occur, if they do occur they may need medical attention Check with your doctor immediately if any of the following side effects occur while taking flutamide: More common side effectsgo drugbank com drugs DB00499--- rxlist com eulexin-drug htmPharmacodynamics Flutamide is a nonsteroidal antiandrogen In animal studies, flutamide demonstrates potent antiandrogenic effects It exerts its antiandrogenic action by inhibiting androgen uptake and or by inhibiting nuclear binding of androgen in target tissues or both Flutamide Dosage and Administration General In patients with stage B2 or C prostate cancer, initiate flutamide and LHRH analog 8 weeks prior to and continue during radiation therapy In patients with stage D2 metastatic prostate cancer, initiate flutamide and LHRH analog concomitantly and continue until disease progression Administration Primarily urine (as flutamide and metabolites); feces (~4%) Time to Peak ~2 hours (2-hydroxyflutamide [active metabolite]) Half-Life Elimination ~6 hours (2-hydroxyflutamide [active metabolite]) Protein Binding Parent drug: 94% to 96%; 2-hydroxyflutamide: 92% to 94% Use in Specific Populations Special Populations: Renal Function Impairment
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