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Low-dose Zopiclone taken before sleep does not deal with this effectively because of the short duration of action of Zopiclone However, just half a 3 75 mg (ca 1 9 mg) via a tablet guillotine is very effective to get 3-4 hrs more good quality sleep with no aftereffects "• taken Zopiclone or other similar medicines for more than 4 weeks • have a history of mental illness • have or have ever had a history of, or tendency to alcohol or drug abuse or personality disorders The risk of dependence to Zopiclone tablets (physical or mental effects produced by a compulsion to keep taking the medicine) increasesThis drug’s effects do not last longer than 12 hours However, zopiclone may still be detectable in urine for 49 hours, and it can be detected in saliva for 59 hours, on average Zopiclone side effects Zopiclone can cause adverse reactions in some people Listed below are some of the most documented side effects See full list on go drugbank com --- drugs com comments zopicloneWhen should I take zopiclone? 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