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Inflammation is the main pathophysiological process involved in atherosclerotic plaque formation, progression, instability, and healing during the evolution of coronary artery disease (CAD) The use of colchicine, a drug used for decades in non-ischemic cardiovascular (CV) diseases and or systemic inflammatory conditions, stimulated new perspectives on its potential application in patients Does colchicine affect the rate of cardiovascular events? cardiovascularbusiness com fda-colchicine-anti-inflammatory-cardiovascula The CLEAR SYNERGY study (NCT03048825) will evaluate whether colchicine (alone or associated with spironolactone) can reduce the 1-year risk of major adverse CV events or a composite of CV death and heart failure Conclusions Colchicine is a sophisticated anti-inflammatory agent that has been used for centuries for the treatment and prevention What is the role of colchicine in cardiovascular protection?
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Jan 19, 2022 · Colchicine treatment and heart failure and myocardial infarction There is a popular belief that inflammatory responses play a role in acute coronary events (ACE) Targeting inflammation could be Colchicine treatment and heart failure and myocardial infarction There is a popular belief that inflammatory responses play a role in acute coronary events (ACE) Targeting inflammation could be Is colchicine a good treatment for cardiovascular disease? Save up to 50% on pet Rx meds and enjoy easy winter care with AutoShip savings Shop now & protect your pet's health for the winter Save up to 50% on Rx and medications
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--- healthline com fda-approves-lodoco-first-anti-inflammatory-drug-for-c Introduction Colchicine , commonly classified as an anti-inflammatory agent, is a mainstay for the treatment of gout and a second-line therapy for other conditions, including pericarditis, familial Mediterranean fever and Behcet’s disease Recent studies suggest that colchicine may be beneficial in a wide spectrum of cardiovascular diseases We carried out a systematic review to investigate The medicinal properties of colchicine have been recognized for centuries Although previously used for gout and familial Mediterranean fever, its immune-modulating, anti-inflammatory, and antifibrotic effects are increasingly recognized as beneficial in the treatment of cardiovascular disorders In this systematic review, we summarize the current evidence on colchicine's effectiveness in 1 Introduction Colchicine, commonly classified as an anti-inflammatory agent, is a mainstay for the treatment of gout and a second-line therapy for other conditions, including pericarditis, familial Mediterranean fever and Behcet’s disease Recent studies suggest that colchicine may be beneficial in a wide spectrum of cardiovascular diseases We carried out a systematic review to investigate Clinical evidence of colchicine for heart attack and stroke prevention The effectiveness and safety of colchicine in preventing heart attack and stroke is supported by randomized trial data reported in the New England Journal of Medicine, Circulation, Journal of the American College of Cardiology, and European Heart Journal [1-4]Does colchicine have anti-inflammatory properties?
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--- amjmed com article S0002-9343(21)00098-X fulltextFeb 10, 2024 · Purpose of Review This review focuses on the use of colchicine to target inflammation to prevent cardiovascular events among those at-risk for or with established coronary artery disease Recent Findings Colchicine is an anti-inflammatory drug that reduces cardiovascular events through its effect on the IL-1β IL-6 CRP pathway, which promotes the progression and rupture of atherosclerotic People also asklink springer com article 10 1007 s11886-024-02026-5What is colchicine used for? Save up to 50% on pet Rx meds and enjoy easy winter care with AutoShip savings Shop now & protect your pet's health for the winter Save up to 50% on Rx and medications
academic oup com eurheartj article 42 28 2745 6271392heart bmj com content 101 Suppl_4 A91 3 Many lines of evidence suggest that inflammation is a key factor in the pathogenesis of cardiovascular disease so it seems plausible that anti-inflammatory treatment might slow or prevent disease progression Colchicine is an anti-inflammatory medication, originally extracted from the autumn crocus plant, that has been used to treat gout for hundreds of years Recently there has been interest
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Purpose of Review This review focuses on the use of colchicine to target inflammation to prevent cardiovascular events among those at-risk for or with established coronary artery disease Recent Findings Colchicine is an anti-inflammatory drug that reduces cardiovascular events through its effect on the IL-1β IL-6 CRP pathway, which promotes the progression and rupture of atherosclerotic Aug 29, 2015 · Background Colchicine has unique anti-inflammatory properties that may be beneficial in various cardiovascular conditions This systematic review and meta-analysis of randomized controlled trials (RCTs) examines this issue Methods We searched MEDLINE, EMBASE, and the Cochrane Database from inception to June 2014 for RCTs using colchicine in adult patients with cardiac diseases Results were cardiovascularbusiness com colchicine-heart-attack-trial-cardiologists-tctThe FDA recently approved the first anti-inflammatory drug for cardiovascular disease called LODOCO (colchicine) The recently approved medication has been shown to reduce cardiac event risk in Wayne Batchelor, MD, director of interventional cardiology with Inova Heart and Vascular Institute, also shared his perspective on these new data “I’m not going to use colchicine,” he said “I think this was a terrific study, really well sample sized for the question, and there is no signal whatsoever other than diarrhea ” A recent metanalysis of randomised controlled trials derived a pooled HR of 0 68 (95% CI, 0 54-0 81) and highlighted that the reduction in cardiovascular events among patients randomized to colchicine was driven by statistically significant reductions in myocardial infarctions (MI), ischemic strokes, and urgent coronary revascularizations academic oup com eurheartj article 45 18 1596 7643185Does colchicine reduce the risk of progressive heart failure after myocardial infarction? --- nature com articles s41401-021-00835-wMay 7, 2021 · The CLEAR SYNERGY study (NCT03048825) will evaluate whether colchicine (alone or associated with spironolactone) can reduce the 1-year risk of major adverse CV events or a composite of CV death and heart failure Conclusions Colchicine is a sophisticated anti-inflammatory agent that has been used for centuries for the treatment and prevention This supports the American Heart Association recommendations that concomitant use of colchicine and statins is safe in patients without advanced renal impairment 28 Accordingly, concerns about myotoxicity should not be a barrier to prescribing low-dose colchicine to patients with coronary disease established on statin therapy in the absence of link springer com article 10 1007 s00392-021-01828-9youtube comyoutube comyoutube com
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