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Pennsaid (diclofenac sodium) is a topical non-steroidal anti-inflammatory drug (NSAID) used to treat the symptoms of Acute Pain, Arthritis Pain, Actinic Keratosis, and Osteoarthritis Serious side effects of Pennsaid include risk of potentially fatal heart attack, stroke, and bleeding, ulceration, and perforation of the stomach or intestines Pennsaid: Diclofenac belongs to the class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs) It works by reducing pain, swelling, and inflammation The topical solution (a lotion applied to the skin) is used to relieve symptoms such as pain associated with osteoarthritis of the knee Feb 9, 2022 · PENNSAID (Diclofenac Sodium Topical Solution) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources Avoid wearing clothing over the PENNSAID-treated knee(s) until the treated knee is dry Protect the treated knee(s) from natural and artificial sunlight Wait until the treated area is dry before applying sunscreen, insect repellant, lotion, moisturizer, cosmetics, or other topical medication to the same knee you have just treated with PENNSAID How do I use Pennsaid? 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